纳米技术在脑疗法中的前景,涉及基因向和鼻至脑注射
Dong-Dong Wu1,2, Yasmine Ahmed Salah1,3, Ebenezeri Erasto Ngowi1,4
1Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
iScience
|August 9, 2023
概括
纳米技术和基因改造生物制剂为通过克服血脑屏障来治疗阿尔茨海默氏症等神经系统疾病提供了新的希望. 鼻内通道对有效提供这些先进疗法充满希望.
科学领域:
- 神经科学是一个神经科学.
- 生物技术是生物技术.
- 纳米医学是一种纳米医学.
背景情况:
- 神经系统疾病对全球健康构成重大挑战.
- 由于血脑屏障 (BBB),常规治疗往往缺乏有效性.
- 纳米技术为向中枢神经系统 (CNS) 提供向药物输送提供了一个有前途的平台.
研究的目的:
- 审查纳米技术和表观遗传学在脑疗法的协同应用.
- 探索基因改变分子 (siRNA,miRNA,CRISPR) 用于治疗神经系统疾病.
- 要突出中枢神经系统药物输送的鼻内通道的进步.
主要方法:
- 对结合纳米技术和表观遗传学用于神经疾病治疗的研究的文献综述.
- 专注于基因改变分子的纳米载体介导传递.
- 分析鼻内注射作为一种输送策略的分析.
主要成果:
- 纳米载体可以被设计为在BBB上有针对性地运送治疗性货物.
- 基因改变生物制剂,包括siRNA,miRNA和CRISPR,在治疗阿尔茨海默病,脑瘤和中风等疾病方面具有潜力.
- 内鼻途径正在成为提供这些纳米药物的有效方法.
结论:
- 纳米技术和表观遗传学的结合为神经疾病治疗提供了一个强大的策略.
- 有针对性的输送系统和新的输送路径,如鼻内输送,对于治疗成功至关重要.
- 这种方法有望开发有效的治疗各种衰弱的大脑疾病的方法.
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