胰岛素样生长因子1预测了补偿性肝硬化患者的脱补偿和长期预后
Chisato Saeki1,2, Tomoya Kanai1,2, Kaoru Ueda1
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Frontiers in medicine
|August 9, 2023
概括
低血清胰岛素样生长因子1 (IGF-1) 水平预测肝硬化患者的预后不佳. 监测IGF-1对于管理补偿性肝硬化和预测脱补偿事件至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 内部医学 内部医学
背景情况:
- 胰岛素样生长因子1 (IGF-1) 是由肝细胞产生的,与肝功能有关.
- 肝硬化是一种严重的肝病,IGF-1在其中起病理作用.
研究的目的:
- 评估血清IGF-1水平对肝硬化患者长期预后和脱补偿的预测值.
- 确定IGF-1水平是否可以帮助管理补偿性肝硬化.
主要方法:
- 对148名肝硬化患者的回顾性评估,根据IGF-1水平 (低,中等,高) 进行了分类.
- 组之间的累积生存率和脱补偿发展的比较.
- 考克斯比例危险回归分析,以确定死亡率和脱补偿的独立预测因素.
主要成果:
- 低血清IGF-1是所有患者和补偿性肝硬化患者死亡率和失补偿的独立预测因子.
- 低IGF-1患者的生存率显著降低,脱补偿发生率更高.
- 在非补偿性肝硬化组之间没有观察到显著的生存差异.
结论:
- 低血清IGF-1水平显着与长期预后不佳和补偿性肝硬化中脱补偿风险增加有关.
- 监测IGF-1对于预测不良事件和指导补偿性肝硬化病的管理是有价值的.
- 血清IGF-1作为评估肝硬化进展和患者结果的潜在生物标志物.
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