对甲状腺激素的敏感性受损与患有2型糖尿病的甲状腺患者的轻度认知障碍有关
Zi-Wei Yu1, Sheng-Dan Pu2, Xiao-Tong Sun2
1Department of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Clinical interventions in aging
|August 9, 2023
概括
甲状腺激素敏感性与2型糖尿病 (T2D) 患者的轻度认知障碍 (MCI) 有关. 较低的外周和更高的中心敏感性与MCI独立相关.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 在2型糖尿病 (T2D) 患者中,轻度认知障碍 (MCI) 的患病率正在上升.
- 甲状腺激素关键调节成人认知功能.
- 在MCI的T2D中调查甲状腺激素敏感性至关重要.
研究的目的:
- 为了检查甲状腺激素敏感性和MCI在 euthyroid T2D个体之间的关联.
- 为了确定外周和中央甲状腺激素敏感度指数是否与认知功能相关.
- 确定与T2D中MCI相关的特定甲状腺激素敏感性标志物.
主要方法:
- 在400名优甲状腺T2D患者 (218名正常认知,182名MCI) 的横截面研究中.
- 使用蒙特利尔认知评估 (MoCA) 评估的认知功能.
- 计算了外围 (FT3/FT4比率) 和中央 (TSHI,TT4RI,TFQI) 甲状腺激素敏感度指数.
主要成果:
- 与对照组相比,MCI患者的FT3/FT4比率较低,TSHI,TT4RI和TFQI较高.
- 摩卡分数与FT3/FT4比率呈正相关,与TSHI,TT4RI,TFQI呈负相关.
- 低FT3/FT4比率和高TSHI,TT4RI,TFQI是MCI的独立预测因素.
结论:
- 甲状腺激素敏感性受损与甲状腺T2D患者的MCI显著相关.
- 周围和中央甲状腺激素敏感度指数提供了对T2D认知状态的见解.
- 这些发现突出了T2D认知衰退的潜在治疗点.
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