一个深度残留模型用于5D时空网络动态的表征,揭示了精神分裂症中广泛的空间动力学变化
Behnam Kazemivash1,2, Theo G M van Erp3,4, Peter Kochunov5
1Department of Computer Science, Georgia State University, Atlanta, GA, United States.
Frontiers in neuroimaging
|August 9, 2023
概括
这项研究揭示了精神分裂症患者大脑网络动态的显著差异. 分析voxel-wise的时空大脑活动突出了独特的模式,这对于理解这种疾病至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 计算生物学 计算生物学
背景情况:
- 精神分裂症是一种严重的大脑疾病,原因不明,可能涉及大脑连接和结构的改变.
- 现有的神经成像研究往往忽略了随着时间的推移在多个大脑网络中的voxel-wise,时空变化.
- 目前专注于静态或固定时间网络变化的方法无法捕捉复杂的,重叠的网络动态.
研究的目的:
- 在精神分裂症中,在多个功能网络内,在声素水平上研究时空大脑动态.
- 开发和应用一个深度学习模型来提取详细的大脑网络特征.
- 为了确定精神分裂症患者和对照人群之间的大脑动态的群体水平差异.
主要方法:
- 利用深度残留卷积神经网络 (CNN) 来提取53个时空大脑网络.
- 将模型应用于来自精神分裂症患者 (N=708) 和对照组 (N=510) 的大型功能磁共振成像 (fMRI) 数据集.
- 分析了多个大脑领域的voxel-wise可变性,大小和时间功能网络连接.
主要成果:
- 揭示了多个大脑网络的时空特征在群体层面上的广泛差异.
- 演示了voxel-wise空间动态产生高度结构化和神经解剖学相关的结果被静态分析遗漏.
- 确定了独特的全球但空间特定的动态模式,使精神分裂症患者与对照患者区别开来.
结论:
- 在全脑神经成像数据中,考虑时间和空间动态是至关重要的.
- 建议的深度学习方法显示了对精神分裂症的高度敏感性,突出了特定群体的动态.
- 这种方法有可能开发用于精神分裂症和其他神经系统疾病的基于大脑的生物标志物.
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