慢性斑块牛皮的维生素D受体表达在狭带紫外线B光疗前后
Lamia H Elgarhy1, Rania A Eltatawy1, Omnia Rizk2
1Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Journal of cutaneous and aesthetic surgery
|August 9, 2023
概括
牛皮涉及遗传,免疫和环境因素. 窄带UVB疗法增加了牛皮皮肤病变中的维生素D受体 (VDR) 表达,这表明这种情况的治疗效益.
科学领域:
- 皮肤病学 皮肤病学
- 分子生物学分子生物学
- 照相疗法 照相疗法
背景情况:
- 牛皮是一种复杂的,多因素的皮肤疾病,受遗传,免疫和环境因素的影响.
- 维生素D受体 (VDR) 在调节表皮细胞生长,包括角质细胞的增殖和分化方面发挥着至关重要的作用.
研究的目的:
- 调查狭带UVB (NB-UVB) 疗法对患有牛皮的患者皮肤中维生素D受体 (VDR) 表达的影响.
主要方法:
- 包括40名患有不同严重程度的牛皮的患者.
- 在24次NB-UVB会议之前和之后收集了皮肤活检 (损伤和非损伤).
- 免疫组织化学被用来评估VDR表达水平.
主要成果:
- 在治疗前,VDR表达在牛皮病变中明显较低,而不是在皮肤上.
- 较低的VDR表达与牛皮区域和严重性指数 (PASI) 评分,家族病史和疾病持续时间负相关.
- NB-UVB疗法导致VDR表达在病变皮肤治疗后显著增加.
结论:
- 在牛皮性皮肤病变中,维生素D受体 (VDR) 表达是下调的.
- NB-UVB疗法通过改善牛皮皮肤病变中的VDR表达而产生积极影响.
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