血清阴性结核病患者的临床概况
Elham Rahmanipour1, Mohammad Ghorbani1, Azita Ganji2
1Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Gastroenterology and hepatology from bed to bench
|August 9, 2023
概括
血清消极性腹病 (SNCD) 影响2.4%的患者,在诊断时呈现出老年和较高的BMI. SNCD是血清阴性肠病的主要原因,与其他胃肠道疾病不同.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 结核病 (CD) 诊断通常依赖于阳性血清学和十二指肠活检结果.
- 一部分患者表现出阴性血清学,尽管表现出CD症状和病理学,称为血清阴性胰腺疾病 (SNCD).
- 在SNCD中延迟诊断可能导致较差的结果和CD相关并发症风险增加.
研究的目的:
- 调查被诊断患有血清阴性结核病 (SNCD) 的患者的临床特征和个人资料.
主要方法:
- 在2010年至2020年期间,对115名被评估患有粘膜缩的CD患者进行了回顾性分析.
- 通过遗传倾向 (DQ2-DQ8阳性) 和经过12个月的无质饮食 (GFD) 后的临床/组织学改善,SNCD诊断得到证实.
- 血清检测包括基于IgA和IgG的测定;具有阳性遗传标记和GFD反应的负结果表明SNCD.
主要成果:
- 在1115名患者中,27名 (2.4%) 被诊断为SNCD,而1088名患者患有血清阳性结核病 (SPCD).
- 在诊断时,SNCD患者的年龄较大 (SPCD患者的年龄为37.1岁,SPCD患者的年龄为29.7岁),BMI较高 (23.9岁,21.4岁).
- 在SNCD中常见的肠外表现包括贫血,神经症状和异常的肝功能测试,与SPCD相比,甲状腺疾病的同时发生率更高.
结论:
- SNCD构成了病病例的很大一部分,其特点是具有明显的人口和临床特征.
- SNCD是血清阴性肠病的主要原因,使其与其他疾病如炎症性肠病和常见的可变免疫缺陷不同.
- 了解SNCD的临床特征对于及时诊断和管理至关重要,以防止长期并发症.
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