血清叶酸:为动脉性勃起功能障碍的有效指标
Xingliang Feng1,2, Yangyang Mei1, Pinpeng Xie3,4
1Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Frontiers in endocrinology
|August 9, 2023
概括
较低的血清叶酸 (FA) 水平与勃起功能障碍 (ED) 的男性阴茎动脉血流减少相关. FA 缺乏是动脉性ED的独立风险因素,影响阴茎内皮功能.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 安德罗学与人类学
- 血管医学 血管医学
背景情况:
- 勃起功能障碍 (ED) 是一种常见的疾病,影响着许多男性.
- 通过阴茎多普勒超声波 (PDU) 测量阴茎动脉缩峰值速度 (PSV) 是阴茎内皮功能的一个关键指标.
- 在ED患者的血清叶酸 (FA) 水平和阴茎血管功能之间的关系仍未得到充分研究.
研究的目的:
- 在勃起功能障碍 (ED) 患者中,研究血清叶酸 (FA) 水平与阴茎动脉缩峰值速度 (PSV) 之间的相关性.
- 为了确定FA水平是否可以作为动脉性ED的预测指标.
主要方法:
- 一项研究包括244名ED患者和72名健康对照.
- 测量了血清FA水平,并对ED患者进行阴茎颜色多普勒超声波 (PDU).
- 用皮尔森相关性和ROC曲线分析来评估FA水平和PDU参数之间的关系.
主要成果:
- 与健康对照组 (10.78 ng/ml) 相比,患有动脉性ED的患者平均血清FA水平较低 (8.08 ng/ml).
- 在动脉性ED患者 (r=0.605,P<0.001) 中,血清FA水平和PSV之间观察到正相关性.
- 血清FA水平,截止值为10.045ng/ml,显示出0.611的灵敏度和0.824的特异性,以区分动脉性ED与对照.
结论:
- 在ED患者中,血清FA水平与阴茎动脉血流 (PSV) 有正相关.
- FA 缺乏被确定为动脉性ED的独立风险因素.
- FA水平可以帮助区分动脉性ED和健康个体.
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