肌素与急性-慢性肝衰竭的存在和发展有关
Astrid Ruiz-Margáin1,2,3, Alessandra Pohlmann4, Silke Lanzerath4
1Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico.
JHEP reports : innovation in hepatology
|August 9, 2023
概括
在肝硬化患者中,较低的肌肉静止素水平与肌肉损失相关,并预测急性至慢性肝衰竭 (ACLF) 和死亡率的发展,无论疾病的严重程度如何.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 肌肉生理学 肌肉生理学
- 生物化学 生物化学
背景情况:
- 急性至慢性肝衰竭 (ACLF) 涉及系统性炎症和线粒体功能障碍.
- 与肌静止素相关的缩症是ACLF的一个拟议机制.
- 肌肉静止素是肌肉损失的一个关键因素.
研究的目的:
- 调查肌肉静止素水平与肝硬化患者ACLF发育之间的关联.
- 评估肌肉静止素在预测肝硬化死亡率中的作用.
- 为了探索肌肉静止素,肉症和肝脏疾病严重程度之间的关系.
主要方法:
- 对186名肝硬化患者进行前性队列研究.
- 对临床,生化和营养参数的评估.
- 使用ROC,卡普兰-梅尔和考克斯回归分析肌静止素水平,ACLF发病率和死亡率.
主要成果:
- 肌静止素水平从补偿性肝硬化逐渐降低到ACLF.
- 低肌静素 (<1,280 pg/ml) 预测了ACLF的发展 (73.6%的肉症患病率).
- 肌静止素水平与ACLF发病率和存活率独立相关.
结论:
- 肌肉静止素水平的逐渐下降伴随着肝硬化的进展.
- 低肌肉静止素表示的肉类,与ACLF的发展和死亡率的增加有关.
- 低肌静素水平是ACLF和肝硬化死亡率的重要预测因素.
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