在AECOPD中血中乙氨基基基水平的预后值受到住院期间皮质类固醇治疗的影响
Jiachen Li1, Lirong Liang1, Lin Feng1
1Department of Clinical Epidemiology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.
Journal of inflammation research
|August 9, 2023
概括
在COPD急性恶化 (AECOPD) 患者中,血中乙氨基基的升高与住院时间缩短以及系统性皮质类固醇治疗的结果更好相关. 这表明,全身类固醇可能有利于eosinophilic AECOPD病例.
科学领域:
- 肺部病理学 肺部病理学
- 生物标志物 生物标志物
- 临床医学 临床医学
背景情况:
- 血中乙氨基细胞计数是用于表型化COPD急性恶化 (AECOPD) 患者的关键生物标志物.
- 了解埃索诺菲尔的预后价值,特别是与皮质类固醇治疗有关的预后价值,对于优化患者管理至关重要.
研究的目的:
- 评估血液中乙氨基基基水平对住院AECOPD患者短期和长期结果的预后意义.
- 根据所接受的皮质类固醇治疗类型来分层这些结果.
主要方法:
- 一项回顾性队列研究包括中国北京的2406名AECOPD住院患者 (2013年7月至2021年6月).
- 在入院后24小时内测量了血液中乙酸细胞的百分比;乙酸性AECOPD被定义为≥2%.
- 分析的结果包括停留时间,治疗失败和3年再录取风险,使用多变量模型以皮质类固醇使用分层 (全身 vs 吸入).
主要成果:
- 较高的乙酸细胞百分比与较短的逗留时间相关 (P趋势=0.014).
- 接受全身性皮质类固醇的乙酸性AECOPD患者的治疗失败风险显著降低 (OR=0.42).
- 吸入性皮质类固醇的乙酸性AECOPD患者仅有90天再入院的风险增加 (HR=1.51),其他再入院期间没有显著差异.
结论:
- 在AECOPD中血中乙氨基细胞的升高与更短的住院时间和对全身性皮质类固醇治疗的更好的反应有关.
- 研究结果表明,全身性皮质类固醇可能对患有乙酸性AECOPD的患者特别有益.
- 治疗策略应考虑乙素水平,以个性化管理AECOPD.
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