皮层和皮层下结构异常在患有异常性宫和通用性 dystonia 的患者
Yunhao Wu1, Tao Wang1, Qiong Ding2
1Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
异形性 dystonia 显示在皮质厚度和皮质下体积的广泛的大脑结构变化,影响宫 dystonia (CD) 和泛型 dystonia (GD) 类似. 这些形态变化与疾病的严重程度和发病年龄相关,这表明共享的机制和潜在的生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 异常性 dystonia 是一种神经运动障碍,其特征是非自愿的肌肉收缩.
- 了解底层的结构性大脑变化在 dystonia 亚型对于阐明疾病机制至关重要.
研究的目的:
- 为了调查皮质和皮质下皮质结构成像改变在异常性 dystonia.
- 为了比较宫性 dystonia (CD) 和泛性 dystonia (GD) 的变化.
- 为了确定与临床特征相关的形态测量测量.
主要方法:
- 3D T1加权的MRI扫描来自56名异形性 dystonia 患者和30名健康对照 (HC).
- 使用CAT12和FSL进行皮层厚度 (CT) 和皮层下体积/形状分析.
- 图像数据与临床特征之间的相关性分析.
主要成果:
- 与HCs相比,在患者中观察到皮质厚度的广泛增加和减少.
- 在CD和GD两种情况下,双边门,尾膜和丘陵体积的显著减少.
- 在GD中减小了皮体积;形状分析显示了乳头和尾骨的变化.
- 在CT,皮下体积和疾病严重程度/发病年龄之间发现的相关性.
结论:
- 异形性 dystonia 与在皮层和皮层以下的广泛的形态变化有关.
- 在CD和GD中异常的类似模式表明共享的潜在机制.
- 影像检测结果的临床关联可以作为 dystonia 研究的潜在生物标志物.
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