相关实验视频

Updated: Jul 19, 2025

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

Published on: February 21, 2018

自动测量和规范化脊髓横截面积使用圆柱骨髓交叉点

Sandrine Bédard¹, Julien Cohen-Adad^1,2,3

¹NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.

Frontiers in neuroimaging

|August 9, 2023

概括

本研究介绍了一种自动化方法来测量脊髓横截面积 (CSA),使用脊髓横截面 (PMJ) 作为参考. 这种方法减少了变异性,并改善了神经退行性疾病中的缩评估.

科学领域:

神经成像是一种神经成像.
生物标志物开发生物标志物开发
神经退行性疾病神经退行性疾病

背景情况:

脊髓横切面积 (CSA) 是神经退行性疾病中脊髓缩的一个关键生物标志物.
目前用于CSA测量的方法具有很高的跨主体可变性,并依赖于使用脊椎水平的不精确的手动正常化.
现有的规范化模型需要人工干预,这限制了它们的临床适用性.

研究的目的:

开发和验证一个自动化管道来测量脊髓CSA,使用一致的神经参考.
调查导致脊髓CSA在个体间变化的因素.
为脊髓CSA测量建立改进的正常化策略.

主要方法:

实施了一条自动化管道,用于脊髓细分和标记,使用来自英国生物银行 (N=804) 的T1wMRI扫描.
脊髓CSA被自动测量,使用带关 (PMJ) 作为空间参考.
逐步回归确定了CSA正常化的显著的人口和解剖学预测因素 (大脑体积,大脑体积,性别).

主要成果:

基于PMJ的自动化CSA测量与C2-C3椎间盘方法 (p=0.0002) 有显著差异.
使用已识别的预测因子进行正常化,PMJ CSA的变化系数降低了14.85%,C2-C3 CSA降低了15.13%.
最好的正常化模型结合了丘脑体积,大脑体积,性别和它们的相互作用.

结论:

成功实施了一个端到端的自动管道,用于从神经参考 (PMJ) 测量和规范脊髓CSA.
开发的规范化策略显著降低了脊髓CSA的个体间变异性.
这种自动化方法为评估脊髓缩提供了更精确和可重复的方法,需要在纵向研究中进一步验证.

关键词:

这就是为什么MRI是MRI.生物标志物生物标志物个体间的变异性.规范化的正常化.脊髓是指脊髓中的一些部分.

更多相关视频

An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury

An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury

Published on: December 31, 2017

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion

Published on: December 10, 2020

相关概念视频

Spinal Cord: Cross-sectional Anatomy

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...

Spinal Cord: Gross Anatomy

Spinal Cord: Gross Anatomy

The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...

The Spinal Cord

The Spinal Cord

The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.