非肥胖型2型糖尿病的全血转录风险评分预测了葡萄糖代谢的动态变化
Yanan Hou1,2, Huajie Dai1,2, Na Chen1,2
1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
一个新的全血转录风险评分 (wb-TRS) 有效预测正常体重个体的2型糖尿病 (T2D) 风险. 这个分数还跟踪葡萄糖代谢的变化,提供了对非肥胖T2D发展的见解.
科学领域:
- 基因组学就是基因组学.
- 代谢疾病研究研究
- 生物标志物发现发现
背景情况:
- 在正常体重个体中对2型糖尿病 (T2D) 风险评估仍然具有挑战性.
- 对于非肥胖T2D风险的外周血液转录标志物尚未得到充分证实.
研究的目的:
- 为非肥胖T2D开发和验证基于全血的转录风险评分 (wb-TRS).
- 评估wb-TRS预测疾病风险和葡萄糖代谢变化的能力.
主要方法:
- 在社区队列 (n=1105,正常BMI,≥40岁) 中开发了144基因转录全血转录风险评分 (wb-TRS).
- 在外部数据集中验证了wb-TRS.
- 使用多对比基因组丰富 (Mitch) 分析探索生物意义.
主要成果:
- 在最高三位数的wb-TRS显示,与最低三位数相比,非肥胖T2D的风险增加了8.91倍.
- 每增加1个单位的wb-TRS与2.63倍更高的非肥胖T2D风险有关.
- 基线wb-TRS与葡萄糖水平,HbA1c和葡萄糖AUC的动态变化显著相关,与临床因素相结合,改善了非肥胖T2D预测.
结论:
- 一个经过验证的基于全血的转录风险评分准确地预测了非肥胖T2D风险和葡萄糖代谢动态.
- 研究结果表明,氧化酸化,mTORC1信号传递和胆固醇代谢途径都与非肥胖T2D病原发生有关.
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