天然产品作为杀虫剂:保护动物健康
Angela A Salim1, Mark S Butler1, Mark A T Blaskovich1
1Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia, 4072. r.capon@uq.edu.au.
Natural product reports
|August 9, 2023
概括
本综述详细介绍了500种天然产品,可以对抗甲虫,甲虫是影响牲畜和物动物的寄生虫虫. 这些化合物显示出开发新类甲虫药物的潜力.
科学领域:
- 兽医寄生虫学 兽医寄生虫学
- 自然产品化学 自然产品化学
- 药物发现 药物发现 药物发现
背景情况:
- 虫感染对牲畜,伴侣动物和野生动物构成重大威胁,影响健康,福利和经济生产力.
- 目前的甲虫药物治疗面临诸多挑战,包括耐药性和潜在的毒性.
- 自然产品是新型抗寄生虫剂的有希望的来源.
研究的目的:
- 在2022年12月之前,全面审查在科学文献中报告的具有抗虫功能的天然产品.
- 对各种虫物种有效的化合物进行分类,包括线虫,虫和带状虫.
- 提供化学结构,源生物和生物活性数据的概述.
主要方法:
- 在2022年12月之前对科学数据库进行系统的文献搜索.
- 包括天然产品和半合成衍生品,据报道对虫有活性.
- 提取有关化学结构,源生物体,除草剂特性,生物试验目标和功效的数据.
主要成果:
- 总共有500种天然产品和17种半合成衍生品被确定具有杀虫剂潜力.
- 化合物证明了对蛋化,运动性,幼虫发育和/或虫生存的有效性.
- 数据涵盖了广泛的源生物和影响不同动物种群的虫物种.
结论:
- 自然产品提供了丰富的资源,用于开发新的防虫疗法.
- 对这些化合物的进一步研究可能会导致兽医中虫感染的新型治疗方法.
- 这篇评论是科学家和研究人员在抗寄生虫药物发现领域的宝贵参考.
相关概念视频
01:28Biological Methods for Microbial Control
64
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
64
01:20Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
251
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
251
01:26Cholinergic Antagonists: Therapeutic Uses
776
Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
776