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一种识别方法,以区分单糖异构体在糖上

Ashley E DeYong1, Jonathan C Trinidad1, Nicola L B Pohl1

  • 1Chemistry, Indiana University, 212 S Hawthorne Dr., Bloomington, IN 47405, USA. trinidad@indiana.edu.

The Analyst
|August 9, 2023
PubMed
概括

自动流合成可快速生产受保护的甘酸氨基酸,以达到甘酸标准. 一种新的LC-MS/MS方法可以区分相似的碳水化合物,在Notch1.1.上识别fucose.

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Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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