多发性硬化症患者康复干预临床试验中的参与者多样性:范围审查
Marcia Finlayson1, Leyan Al-Mashita2, Rebekah Sandhu3
1School of Rehabilitation Therapy, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.
Multiple sclerosis (Houndmills, Basingstoke, England)
|August 9, 2023
概括
多发性硬化症 (MS) 康复的临床试验缺乏多样化的参与者和全面的报告. 改进招聘和参与者描述对于概括性和基于证据的护理至关重要.
科学领域:
- 康复医学 康复医学 康复医学
- 临床试验方法论 临床试验方法论
- 医疗保健服务研究 医疗服务研究
背景情况:
- 临床试验中参与者的多样性对于发现的概括性至关重要.
- 试验的有限多样性限制了医疗保健提供者的基于证据的决策.
- 了解参与者特征可以确保结果适用于不同患者群体.
研究的目的:
- 评估多样性硬化症 (MS) 康复临床试验中多样性参与者的纳入.
- 评估MS康复研究中参与者特征的报告.
- 在MS康复试验中确定参与者选择和描述的局限性.
主要方法:
- 自2002年1月以来发表的多发性硬化症康复试验的范围审查.
- 在MEDLINE,CINAHL和Web of Science数据库中进行的搜索.
- 数据提取侧重于干预细节,结果和参与者描述符,使用健康的社会决定因素框架.
主要成果:
- 包括243项研究,运动干预和以损伤为中心的结果是最常见的.
- 招聘主要通过MS诊所进行,常见的排除标准包括并发病,残疾,年龄和认知障碍.
- 经常报告参与者的年龄和性别,但很少描述健康的其他社会决定因素.
结论:
- 多发性硬化症康复试验表现出有限的招募策略和受限的参与者样本.
- 在已发表的多发性硬化复杂症康复试验中,缺乏全面的参与者描述.
- 加强参与者多样性和详细的特征报告是改善临床适用性和基于证据的实践所必需的.
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