一个开源平台,用于固定头部操作者和消费行为
Adam Gordon-Fennell1, Joumana M Barbakh1, MacKenzie T Utley1
1Center for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, United States.
eLife
|August 9, 2023
概括
我们开发了OHRBETS,这是一个负担得起的,开源的系统,用于固定头部的动物行为研究. 这个平台能够精确研究动机行为和神经活动,促进神经科学发现.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 生物医学工程 生物医学工程
背景情况:
- 固定头部的动物模型为研究行为和神经活动提供了高度的实验控制.
- 研究激发行为的神经基础需要灵活而精确的实验平台.
研究的目的:
- 推出OHRBETS (开源头固定动物行为实验训练系统),这是一个低成本的开源平台.
- 证明OHRBETS在复制关键行为现象型和启用新型实验范式方面的能力.
主要方法:
- OHRBETS平台:用于行为控制和数据采集的集成硬件和软件.
- 行为任务:操作者调节,光遗传学内自我刺激,实时位置偏好和多孔短暂访问消费.
- 神经记录:在消费任务期间测量出的中膜多巴胺信号.
主要成果:
- 使用OHRBETS的头部固定小鼠表现出与自由移动条件相比的操作条件和消费行为.
- 该系统成功支持光遗传学自我刺激和实时位置偏好测试.
- 在多口喷任务中的行为与溶液度相关,并由昼夜/静态因素调节.
- 梅索林比克多巴胺信号与相对溶液值和消耗大小有很强的相关性.
结论:
- OHRBETS为头固定动物行为神经科学提供了一种多功能,具有成本效益和开源解决方案.
- 该平台促进了动机行为可复制的研究,并允许与体内神经记录/扰动技术进行集成.
- OHRBETS使研究人员能够以更高的精度和可访问性研究复杂行为的神经支柱.
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