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使用生成性深度学习框架的 κ-阿片类受体对手的 De Novo 设计

Leslie Salas-Estrada1, Davide Provasi1, Xing Qiu1

  • 1Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

Journal of chemical information and modeling
|August 9, 2023
PubMed
概括

卡帕-阿片类受体 (KOR) 的药理阻塞可以通过减少奖励缺陷来治疗阿片类成. 这项研究使用深度学习来设计新的KOR抗剂,显示出成治疗的前景.

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