如何使用百分比来更好地理解标准化平均差异 (SMD) 作为效果大小的衡量标准
1Department of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences, Bangalore, India (candrade@psychiatrist.com).
The Journal of clinical psychiatry
|August 9, 2023
概括
标准化平均差异 (SMD) 很难掌握. 将SMD转换为百分比分数,可以更清楚地了解现实世界的影响,特别是在阿尔茨海默病等疾病的临床研究中.
科学领域:
- 医学研究中的统计数据.
- 临床试验数据解释
- 心理测量分析 心理测量分析
背景情况:
- 标准化平均差异 (SMD) 是一种用于量化效应大小的统计计计量.
- 传统的SMD解释 (小,中,大) 缺乏现实世界的临床背景.
- 了解统计学显著发现的临床意义可能是具有挑战性的.
研究的目的:
- 提出一种方法来提高对标准化平均差异 (SMDs) 的理解.
- 为了证明如何将SMD转换为百分点得分可以提高解释性.
- 为了说明这种转换方法的实际应用,使用阿尔茨海默氏症和帕金森病的元分析.
主要方法:
- 该研究解释了将SMD转换为百分比分数的逐步程序.
- 它使用对阿尔茨海默氏症和帕金森病的胆酶抑制剂 (ChEIs) 的元分析作为案例研究.
- 该方法涉及使用标准的正常曲线表来找到与SMD值相对应的百分点得分.
主要成果:
- 胆酶抑制剂在阿尔茨海默氏症和帕金森病中显示出具有统计学意义的效应 (SMDs-0.08至-0.14).
- 转换为百分点得分显示了适度的患者平均改善 (3-7个百分点位).
- 结果表明,从统计学上显著的发现可能并不总是转化为临床上可观察到的效应.
结论:
- 将SMD转换为百分点得分可以更直观地理解效果大小.
- 这种方法有助于评估研究结果的临床意义,而不仅仅是统计意义.
- 该程序简单,快速,并提高了对更广泛的受众的元分析结果的解释性.
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