碳氧甲基纤维素人工眼对眼睛表面微生物群多样性和组成的影响,随机对照试验
Yujia Zhou1,2, Gurjit S Sidhu3, Joan A Whitlock3
1Department of Ophthalmology, University of Florida Shands Hospital, Gainesville, FL, USA.
Translational vision science & technology
|August 9, 2023
概括
碳氧甲基纤维素人工眼不会改变眼睛表面微生物群的多样性. 虽然一些细菌种群发生了变化,但这种成分在干眼治疗中并不比聚乙烯糖醇更有效.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 碳氧甲基纤维素 (CMC) 是常见的人工眼的成分.
- 摄入的CMC减少了肠道微生物群的多样性.
- CMC对眼睛表面微生物群的影响尚不清楚.
研究的目的:
- 研究CMC人工眼对眼睛表面微生物群多样性和组成的影响.
- 为了比较CMC的人工眼与聚乙烯糖醇 (PEG) 人工眼.
主要方法:
- 一项随机对照试验,涉及80名健康成年人.
- 参与者使用CMC或PEG人工眼七天.
- 用16S rRNA测序分析了结膜拭子的微生物群多样性和组成.
主要成果:
- 无论是CMC还是PEG人工眼都没有显著改变整体微生物群的多样性 (Chao-1,Shannon指数).
- 据LEfSe分析显示,CMC减少了Bacteroides和Lachnoclostridium的含量,但增加了Enterobacteriaceae,Citrobacter和Gordonia的含量.
- 这两种干预措施都改善了眼部表面疾病指数 (OSDI) 的得分,两组之间没有显著差异.
结论:
- CMC人工眼不会影响眼睛表面微生物群的多样性.
- CMC人工眼诱导细菌种群的微小变化,增加了Actinobacteriota,同时减少了Bacteroides和Firmicutes.
- CMC和PEG人工眼在改善干眼症状方面表现出类似的有效性.
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