在患有全身性红斑狼的女性中,比较了两个脆弱性定义
Sarah B Lieber1,2, Musarrat Nahid2,3, Alexandra Legge4
1Division of Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, NY, USA.
Rheumatology (Oxford, England)
|August 9, 2023
概括
脆弱性影响17.9-26.9%的女性有系统性红斑狼 (SLE). 现型 (FP) 和SLICC脆弱性指数 (SLICC-FI) 均确定了脆弱的个体,这些个体经历了更大的残疾.
科学领域:
- 类风湿病学 类风湿病学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 虚弱是系统性红斑狼 (SLE) 患者不良健康结果的重要危险因素.
- 形表型 (FP) 和SLICC脆弱性指数 (SLICC-FI) 是用于评估脆弱性的不同的指标.
- 了解脆弱性患病率及其影响对于管理SLE患者至关重要.
研究的目的:
- 为了比较患有SLE的女性的脆弱性患病率,使用化表型 (FP) 和SLICC脆弱性指数 (SLICC-FI).
- 根据每个脆弱度指标,描述脆弱与非脆弱参与者的特征.
- 评估每个虚弱度指标与SLE妇女自我报告的残疾之间的关联.
主要方法:
- 一项横截面研究招募了67名患有SLE的18至70岁妇女.
- 脆弱性是使用形表型 (FP) 和SLICC脆弱性指数 (SLICC-FI) 进行评估的.
- 评估了疾病活动,损伤和自我报告的残疾 (使用PROMIS和VLA).
主要成果:
- 虚弱的流行率是17.9%的FP和26.9%的SLICC-FI (卡帕=0.41,P<0.01).
- 与非脆弱女性相比,通过任何一项指标识别的脆弱女性表现出明显更大的疾病损伤,更差的PROMIS分数和更高的自我报告残疾 (所有P <0.01).
- 根据年龄调整的分析表明,虚弱与FP (OR 4.7) 和SLICC-FI (OR 4.6) 的残疾概率增加有关.
结论:
- 脆弱性在17.9-26.9%的SLE女性中普遍存在,通过FP和SLICC-FI进行明显但重叠的识别.
- 这两种脆弱度指标都确定了类似的女性群体,她们经历了更大的残疾和疾病负担.
- 需要进一步的研究来确定哪种脆弱度量是SLE妇女在临床上最有信息的.
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