乳腺癌幸存者的酒精消费,预后和生存率:通路研究
Marilyn L Kwan1, Emily Valice1,2, Isaac J Ergas1
1Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Cancer
|August 9, 2023
概括
乳腺癌诊断后短期的酒精摄入显示出各种各样的影响. 肥胖女性的死亡风险较低,而非肥胖女性面临潜在的复发风险增加.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 饮酒与乳腺癌 (BC) 预后之间的关系尚未得到充分证实.
- 了解短期酒精摄入的影响对于患者指导至关重要.
研究的目的:
- 调查短期饮酒与乳腺癌复发和死亡率之间的关联.
- 探索基于体重指数 (BMI) 的潜在差异效应.
主要方法:
- 这项研究分析了2003年至2013年期间被诊断患有I-IV期乳腺癌的3659名妇女的数据.
- 在诊断时和诊断后6个月使用食物频率问卷评估酒精摄入量.
- 多变量考克斯比例危险模型用于估计危险比率 (HRs) 和95%置信区间 (CI).
主要成果:
- 在11.2年的随访期间,记录了524例复发和834例死亡.
- 总的来说,酒精消费与复发或死亡率没有显著关联.
- 肥胖妇女 (BMI ≥30 kg/m2) 显示,随着增加酒精摄入,所有原因的死亡风险的剂量反应下降.
- 非肥胖女性 (BMI <30 kg/m2) 呈现出非显著的趋势,即与饮酒相关的复发风险较高.
结论:
- 乳腺癌诊断后6个月左右的酒精消费与肥胖女性全因死亡率的降低有关.
- 在非肥胖女性中观察到潜在的复发风险增加,需要进一步调查.
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