透明细胞中的多核瘤细胞 细胞癌
Richard R Pacheco1, Busem Binboga Kurt2, Kemal Kosemehmetoglu3
1Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY, US.
American journal of clinical pathology
|August 9, 2023
概括
清细胞细胞癌 (ccRCC) 中的多核瘤细胞 (MTC) 可能表明预后较差. 带有的MTC (MTCA) 和没有的MTC (MTCNA) 预测ccRCC患者的复发和转移风险更高.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 多核瘤细胞 (MTC) 在清细胞细胞癌 (ccRCC) 中被观察到,但它们的预后意义尚不清楚.
- 将MTC分为不同的亚型可以提供关于ccRCC行为和患者结果的见解.
研究的目的:
- 研究ccRCC中不同MTC亚型的临床病理学特征和预后影响.
- 确定MTC亚型与瘤侵略性,转移潜力和患者存活率之间的关联.
主要方法:
- 对2010年至2019年期间诊断的256例ccRCC病例进行了回顾性分析.
- 将MTC分类为具有退行性异位症 (MTCD) 的MTC,没有阿纳普拉西亚的MTC (MTCNA) 和具有阿纳普拉西亚的MTC (MTCA).
- 在使用统计分析 (包括考克斯回归) 的MTC组中比较临床病理特征和结果 (复发,转移,生存).
主要成果:
- 36%的ccRCC病例 (92/256) 呈现了MTC.
- 在MTCD病例中,结果与没有MTC的ccRCC相似.
- MTCNA和MTCA与较大的瘤大小,晚期,更高的核级别和更高的转移潜力 (P < .001) 有显著的关联.
- MTCA独立预测了更高的复发率 (P = .004),更大的转移潜力 (P < .001),以及更短的转移时间 (P = .033).
- 在5年内,MTCNA预测了转移 (HR 4.171),而MTCA预测了复发 (HR 5.723),转移 (HR 12.024) 和死亡 (HR 5.661).
结论:
- 虽然MTCD可能不会影响ccRCC分级,但MTCNA和MTCA是不利结果的重要指标.
- 在ccRCC中MTCNA和MTCA的存在需要仔细考虑,因为它们与侵袭性疾病和更差的预后有关.
- 建议对MTC形成的生物学机制及其在ccRCC进展中的作用进行进一步的研究.
相关概念视频
01:20Renal Corpuscle
2.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.6K
02:30Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
01:24Renal Tubule and Collecting Duct
1.1K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
1.1K