长期COVID脑雾的特征:一个回顾性队列研究
Grace Y Lam1,2, Ronald W Damant3,4, Giovanni Ferrara3,4
1Division of Pulmonary Medicine, Department of Medicine, University of Alberta and Alberta Health Services, 3-111C Clinical Sciences Building, 11302 83 Ave NW, Edmonton, AB, T6G 2G3, Canada. glam@ualberta.ca.
Journal of neurology
|August 9, 2023
概括
长期COVID神经认知障碍与特定的风险因素和免疫差异有关. 早期识别有风险的个体可以指导更密集的医疗随访,以便更好地康复.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 后COVID状态 (PCC) 经常涉及神经认知障碍,影响所有年龄段的人.
- 风险因素,生物标志物和PCC相关的神经认知症状的临床进展仍然不明.
研究的目的:
- 为了在PCC队列中比较患有和没有神经认知障碍 (NC+与NC-) 的患者的临床风险因素,生化标志物和纵向轨迹.
- 确定与PCC患者神经认知障碍相关的独立风险因素.
主要方法:
- 使用已确认PCC患者的省级数据库进行了回顾性纵向队列研究.
- 在初始咨询时对人口统计,临床和生化数据进行横截面分析.
- 多变量回归用于识别神经认知障碍的危险因素.
- 使用Eq-5D-5L-vas分数对与健康相关的生活质量 (HR-QoL) 的纵向评估.
主要成果:
- 神经认知障碍的独立风险因素包括女性,经历轻度急性感染,以及先前存在的心理健康诊断.
- 与NC+患者相比,神经认知障碍 (NC+) 患者的IgG,IgG1和IgG3水平较低.
- NC+队列在感染后8个月报告HR-QoL较差,在20个月内逐渐改善.
结论:
- 神经认知障碍是一种严重的PCC表型,具有明显的风险因素,免疫系统异常和漫长的恢复.
- 早期识别患有神经认知障碍风险的个体对于及时和密集的医疗干预至关重要.
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