儿童脏移植中与脱水相关的住院病例
Amelia K Le Page1,2, Lilian M Johnstone3,4, Joshua Y Kausman5,6,7
1Department of Nephrology, Monash Children's Hospital, Clayton, VIC, Australia. Amelia.LePage@monashhealth.org.
Pediatric nephrology (Berlin, Germany)
|August 9, 2023
概括
在移植后的儿童中,脱水入院是常见的. 较高的液体摄入量目标和青少年年龄增加风险,而肠道养管可能无法防止与疾病相关的脱水入院.
科学领域:
- 儿科脏病学 儿科脏病学
- 移植免疫学 移植免疫学
- 临床儿科 临床儿科
背景情况:
- 儿科移植接受者因功能受损和疾病而面临脱水风险.
- 脱水会导致肌水平升高,这可能导致这种脆弱人群的住院治疗.
- 这项研究调查了移植后12个月内因脱水而导致移植功能障碍的入院病例.
研究的目的:
- 描述儿童移植受体中与脱水相关的移植功能障碍的住院病例.
- 确定导致这些脱水相关入院的风险因素.
主要方法:
- 从两个三级儿童医院的儿科患者的医疗记录中提取回顾性数据.
- 描述性分析和多次失败回归以确定与脱水相关的急性移植异能相关的因素.
主要成果:
- 在92名儿童中,42%的儿童在移植后12个月内至少有一次脱水入院.
- 缺乏水分摄入量占了近一半的脱水入院病例.
- 液体摄入目标>100毫升/公斤/天 (HR 2.04) 和青少年年龄 (HR 4.87) 与脱水入院相关;肠道食管 (HR 2.18) 与与疾病相关的入院相关.
结论:
- 在小儿移植后的第一年,脱水入院很常见.
- 鉴定的风险因素需要进一步研究移植受体及其护理人员的最佳液体摄入和水分化策略.
- 肠道食管可能无法完全预防与潜在疾病相关的脱水.
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