神经精神病学参与青少年发作的全身性红斑狼 (jSLE)
Valentina Natoli1,2,3, Amandine Charras1, Gabriele Hahn4
1Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
青春期开始的全身性红斑狼 (jSLE) 患者表现出显著的神经精神疾病 (NP) 参与,影响13.5-51%. 本综述提出了两个不同的NP-jSLE子组,帮助未来的个性化治疗策略.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 系统性红斑狼 (SLE) 是一种罕见的自身免疫性疾病,患病率很高.
- 青少年发病的SLE (jSLE) 呈现出比成人发病的SLE更严重和更可变的疾病.
- 神经精神病 (NP) 参与是jSLE的严重并发症,但其发病率和病理生理学知之甚少.
研究的目的:
- 审查关于青少年发病SLE (jSLE) 中神经精神病学参与的现有文献.
- 为NP-jSLE提出潜在的病理生理学子组.
- 为未来的研究和患者分层提出建议.
主要方法:
- 关于NP参与jSLE的已发表报告的文献综述.
- 对临床表现的分析和建议的潜在机制.
- 为NP-jSLE亚型生成假设.
主要成果:
- 在13.5-51%的jSLE患者中报告了神经精神病学的参与.
- 中枢神经系统 (CNS) NP-jSLE的两个建议子组:慢性,干扰素驱动的形式和急性,淋巴细胞介导的形式.
- 目前的治疗方法在慢性渐进的形式中显示出有限的疗效.
结论:
- 神经精神病学的参与是JSLE的一个重大问题.
- 拟议的分为慢性和急性形式的分类需要在大群体中进行验证.
- 这种分层可能会导致个性化的患者护理和改善NP-jSLE的治疗结果.
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