术后的苏芬坦尼尔消费和术后恶心和/或吐的风险:一项回顾性观察性研究
Ran Zhang1, Wei Xin Zhang1, Xiao Ran Ma1
1Department of Anesthesiology and Pain Medicine, Peking University People's Hospital, Beijing, China.
Pain and therapy
|August 9, 2023
概括
在胸腔镜手术患者中,较高的手术内sufentanil使用 (twSuf > 0.21 μg kg−1 h−1) 与术后恶心和吐 (PONV) 风险增加有关. 这一发现强调了监测手术内阿片类药物消费的重要性,以管理PONV.
科学领域:
- 麻醉学 麻醉学
- 外科手术的结果
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后恶心和/或吐 (PONV) 是手术后的常见并发症.
- 一种阿片类止痛药苏芬坦尼尔与PONV有关,但手术内苏芬坦尼尔剂量与PONV之间的联系需要进一步调查.
研究的目的:
- 调查手术内施用苏芬坦尼尔与PONV发病率之间的关联.
- 在接受视频辅助胸腔镜手术的患者中识别PONV的风险因素.
主要方法:
- 一项追溯观察性研究,涉及2733名接受胸腔镜手术的患者.
- 患者接受了整体麻醉和手术前的胸部副脊椎阻塞.
- 后勤回归分析用于确定术后第一天与PONV相关的因素.
主要成果:
- 总体PONV发生率为5.2% (143/2733名患者).
- 与PONV相关的因素包括女性性别,非吸烟者身份,苏芬坦尼尔患者控制的静脉静脉止痛 (PCIA),术后阿片类药物消耗和手术内苏芬坦尼尔剂量 (twSuf).
- 超过0.21μg kg-1h-1的时间加权平均手术内sufentanil剂量 (twSuf) 被确定为PONV的独立风险因素.
结论:
- 在手术内给予苏芬坦尼尔,特别是twsuf>0.21微克每公斤-1小时-1,显著增加了PONV的风险.
- 这些发现对于在全身麻醉下进行胸腔镜手术的患者治疗PONV至关重要.
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