在使用辅助生殖技术后,母亲患心血管疾病的风险
Maria C Magnus1, Abigail Fraser2,3, Siri E Håberg1
1Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
JAMA cardiology
|August 9, 2023
概括
在辅助生殖技术 (ART) 后分娩的妇女在11年的随访期间没有显示出心血管疾病 (CVD) 的风险增加. 需要进一步的长期研究来证实这些关于ART和心血管疾病风险的发现.
科学领域:
- 生殖医学 生殖医学
- 心血管健康 心血管健康
- 流行病学 流行病学
背景情况:
- 在全球范围内,辅助生殖技术 (ART) 的使用正在增加.
- 在ART后的长期健康结果,包括心血管疾病 (CVD) 风险,尚未得到充分确立.
- 有限的研究和随访时间阻碍了对ART对长期健康的影响的理解.
研究的目的:
- 研究ART后分娩与患心血管疾病 (CVD) 的风险之间的关联.
- 为了比较通过ART怀孕的个体与自然怀孕的个体的心血管疾病风险.
主要方法:
- 一项大规模的基于注册表的队列研究利用了来自丹麦,芬兰,挪威和瑞典 (1984-2015) 的全国数据.
- 包括有超过240万个注册出生的人,其中97,474人是在ART后分娩的.
- 评估心血管疾病 (CVD) 风险是使用Cox比例危险回归,调整多个共变量.
主要成果:
- 在11年的中位随访期间,在ART后分娩的个体中没有观察到整体心血管疾病 (CVD) 的风险增加 (调整后危险比率 [AHR],0.97;95% CI,0.91-1.02).
- 没有发现缺血性心脏病,脑血管疾病,中风,心肌病,心力衰竭,肺栓塞或深静脉血栓形成的风险有显著差异.
- 观察到心肌梗塞风险的适度降低 (AHR,0.80;95% CI,0.65-0.99),国家之间没有显著的异质性.
结论:
- 在辅助生殖技术 (ART) 后分娩与心血管疾病 (CVD) 风险增加无关,平均随访时间为11年.
- 这些发现表明,ART与中期内较高的心血管疾病风险无关.
- 建议进行更长期的研究,以充分了解ART与心血管健康之间的关系.
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