抗原特异性CD4 T细胞和B细胞对Borrelia burgdorferi的反应
Elizabeth M Hammond1,2,3, Kimberly J Olsen2,3, Shivneel Ram2
1Graduate Group in Immunology, University of California, Davis, Davis, CA.
Journal of immunology (Baltimore, Md. : 1950)
|August 9, 2023
概括
对莱姆病细菌Borrelia burgdorferi的长期适应性免疫反应无法发展. 这项研究表明,在维持T卵泡辅助细胞和B细胞方面存在缺陷,而不是在最初的诱导过程中.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 持续的Borrelia burgdorferi感染,是莱姆病的原因,损害了长期存在的T-依赖B细胞反应.
- 有限的试剂阻碍了对特定于B. burgdorferi的适应性免疫细胞的研究.
研究的目的:
- 调查针对Borrelia burgdorferi的适应性免疫反应的诱导和功能.
- 开发追踪B. burgdorferi特异性的CD4T细胞的方法.
主要方法:
- 产生一种B. burgdorferi突变体,表达一种用于追踪T细胞的流感血素 (HA) .
- 开发针对Arp特异性CD4T细胞的I-Ab受限制的MHCII类四度体.
- 感染小鼠T毛囊辅助细胞和B细胞的流细胞计分析.
主要成果:
- 在感染了B. burgdorferi arp::HA菌株的小鼠中,TCR转基因CD4 T细胞没有扩张.
- 在B. burgdorferi感染的小鼠中检测到Arp特定的CD4T细胞,其中的一个子集被确定为T毛囊辅助细胞.
- 在生殖中心突出之前,T毛囊辅助细胞数量下降,B细胞频率与抗体水平没有相关性.
结论:
- 数据表明,Borrelia burgdorferi特有的T毛囊辅助细胞和B细胞的维持失败.
- 这表明适应性免疫反应的维护阶段存在缺陷,而不是最初的诱导.
相关概念视频
B Cell Activation and Differentiation
1.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.8K
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Special Features of Adaptive Immunity
874
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
874
T Cell Activation and Clonal Selection
808
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
808
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Humoral Immune Responses
73.0K
Overview
73.0K


