在肥胖的环境中,肺炎症的存活率会导致持续的脂肪肝炎和代谢功能障碍
Avnee J Kumar1, Chitra Parthasarathy1, Hallie C Prescott1,2
1Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Hepatology communications
|August 9, 2023
概括
患有非酒精性脂肪性肝病 (NAFLD) 的败血症幸存者经历了葡萄糖代谢和肝炎的改变. 肥胖患者在败血症后也面临更高的肝损伤风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 关键护理医学 关键护理医学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 败血症幸存者的越来越多的人口带来了挑战,包括持续的器官炎症,特别是在肝脏.
- 非酒精性脂肪性肝病 (NAFLD) 越来越普遍,引发了人们对其与败血症的相互作用的担忧.
- 了解败血症对先前存在的NAFLD和高血糖的长期影响至关重要.
研究的目的:
- 在小鼠模型中调查败血症对先前存在的非酒精性脂肪性肝病 (NAFLD) 和高血糖症的长期影响.
- 为了探索肥胖和肝损伤之间的关系,在血症患者.
主要方法:
- 吃高脂肪或控制饮食的雄性小鼠感染了Klebsiella肺炎 (Kpa).
- 进行了葡萄糖耐受性,胰岛素和pyruvate挑战测试,以及肝脏RNA测序和组织学.
- 对65,139名患者的回顾性分析评估了肥胖和败血症后肝损伤之间的联系.
主要成果:
- 吃高脂肪饮食的小鼠表现出皮鲁酸盐利用率下降和肝炎后败血症,具有独特的炎症基因特征.
- 临床队列中的肥胖 (预肥胖,第1类和第2类) 与败血症后1-2年内氨基转移酶水平升高相关.
结论:
- 饮食诱导的肥胖症与小鼠的败血症存活率相结合,导致葡萄糖生成和肝炎的改变,脂肪酸症进展为脂肪肝炎.
- 肥胖患者在败血症后1-2年表现出肝酶升高的风险增加.
相关概念视频
01:30Pneumonia V: Nursing management and Prevention
2.2K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.2K
01:29Pneumonia II: Pathophysiology
339
The pathophysiology of pneumonia involves the following steps:
339
01:30Pneumonia I: Introduction
269
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
269
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.8K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.8K
01:30Pneumonia III: Complications and Assessment
266
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
266
01:22Chronic Obstructive Pulmonary Disease
1.3K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.3K