寻求治愈:COVID-19潜在的小分子治疗方法,第二部分
1sp3 Pharma Consulting, 6755 Mira Mesa Boulevard, STE123-217, San Diego, California 92121, United States.
概括
本综述更新了remdesivir和molnupiravir的合成,并检查了用于COVID-19治疗的甲合成. 虽然没有治愈方法,但这些药物开发在控制大流行病方面取得了进展.
科学领域:
- 制药化学 制药化学 制药化学
- 传染性疾病 传染性疾病
- 药物开发 药物开发
背景情况:
- 随着COVID-19大流行,药物被广泛重新使用和开发.
- 最初的治疗方法有效性有限,因此需要对治疗选择进行持续的研究.
研究的目的:
- 为关键的COVID-19候选药物提供合成途径的最新审查.
- 为了突出最近的remdesivir,molnupiravir和dexamethasone的合成进展.
主要方法:
- 审查最近发表的用于remdesivir的合成方法.
- 对molnupiravir的各种合成途径的概述.
- 检查德克萨米他的既定和新型合成路径.
主要成果:
- 雷梅西维尔 (Veklury) 在美国和欧洲获得了监管批准.
- 德克萨米他在严重的COVID-19病例中显著降低了死亡率.
- 口服抗病毒药物Molnupiravir正在通过后期临床试验进行进展.
结论:
- 药物合成的持续进步对于打击COVID-19至关重要.
- 已批准和正在研究的药物,如雷梅西维尔,德克萨米他和莫尔努皮拉维尔,在流行病管理方面取得了重大进展.
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