相关实验视频

Updated: Jul 19, 2025

Probiotic Studies in Neonatal Mice Using Gavage

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

婴儿,虫子和大脑:早期微生物组如何与婴儿大脑和行为发展相关联

Sebastian Hunter¹, Erica Flaten², Charisse Petersen^3,4

¹Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.

|August 9, 2023

概括

早期婴儿肠道微生物组的组成显示出与认知发育的潜在联系,包括社会注意力和神经节律跟踪. 需要进一步的研究来证实这些婴儿大脑-肠轴的发现.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
发展心理学发展心理学

背景情况:

肠-大脑轴在神经发育中起着至关重要的作用.
早期的微生物群殖民影响大脑的成熟和健康.
假设婴儿微生物组相互作用促进认知功能.

研究的目的:

调查婴儿肠道微生物群组成和早期认知发育措施之间的关联.
检查了神经节奏跟踪,语言歧视和社会联合注意力.

主要方法:

来自56名婴儿 (4-6个月大) 的便样本的枪式基因组测序.
通过点和凝视测试来评估联合注意力.
用功能近红外光谱学 (fNIRS) 测量语言歧视和用电脑电图 (EEG) 追踪神经节律.

主要成果:

联合注意力成功与Actinobacteria增加,Firmicutes减少和特定的属性变化 (例如,Bifidobacterium增加) 有关.
神经节律跟踪与特定的细菌丰度和代谢途径相关 (例如,分支链氨基酸生物合成).
通过fNIRS.没有发现任何关于语言歧视的重要协会.

结论:

试点研究确定了婴儿肠道微生物组与早期认知发育标志物之间的潜在联系.
研究结果表明,微生物组可能会影响社会注意力和神经处理.
需要进一步的研究来验证这些微生物组-肠-大脑轴的关联.

更多相关视频

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

相关概念视频

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...

Socioemotional Development during Infancy

Socioemotional Development during Infancy

Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

The Nativist Approach

The Nativist Approach

The nativist approach to infant cognitive development proposes that infants are born with inherent knowledge structures that allow them to interpret the world almost immediately. This perspective contrasts with earlier developmental theories, such as those proposed by Jean Piaget, which emphasized a more gradual acquisition of cognitive abilities through interaction with the environment. One key concept in this approach is object permanence — the understanding that objects continue to...