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哺乳模式与人乳微生物组合有关:母婴微生物组,行为和生态研究 (MIMBES)
Elizabeth A Holdsworth1, Janet E Williams2, Ryan M Pace3
1Department of Anthropology, Washington State University, Pullman, Washington, United States of America.
PloS one
|August 9, 2023
概括
哺乳频率和婴儿护理影响人乳微生物组 (HMM) 组成. 特定的母乳养模式影响母乳中的细菌多样性和丰富性,这表明生态因素塑造了HMM.
科学领域:
- 微生物学 微生物学
- 人类生态人类生态学
- 婴儿营养 婴儿营养
背景情况:
- 人母乳微生物组 (HMM) 对婴儿发育至关重要.
- HMM的播种受到婴儿口腔微生物组等因素的影响.
- 哺乳模式对HMM成分的影响仍未得到充分研究.
研究的目的:
- 调查母乳养模式 (频率,持续时间) 与HMM组成之间的关联.
- 探索婴儿护理网络对HMM多样性和细菌丰富性的影响.
- 分析母乳养行为与HMMα多样性和特定细菌基因之间的关系.
主要方法:
- 利用了母婴微生物组,行为和生态学研究 (MIMBES) 的数据.
- 用16S rRNA基因测序分析了46个母婴双的牛奶样本.
- 采用多重线性回归和ANCOM-BC来评估HMM与母乳养/护理因素之间的关联.
主要成果:
- HMM丰富度与母乳养发作频率和所有母亲接触相反相关.
- 婴儿的非家庭护理网络与HMM均度正相关.
- 特定的细菌系,包括Bifidobacterium,表现出与母乳养频率和持续时间相关的不同丰度.
结论:
- 哺乳模式和婴儿护理生态显著影响HMM的组成.
- 研究结果表明,婴儿护理实践和牛奶微生物群之间存在动态相互作用.
- 需要进一步的研究来探索这些不同人群之间的关系及其对婴儿肠道微生物组的影响.
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