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在炎症性肠病患者中SARS-CoV-2mRNA接种疫苗后的接种后症状:一个前性,比较性研究
Angela Mujukian1, Rashmi Kumar1, Dalin Li1
1Inflammatory Bowel and Immunobiology Research Institute, Karsh Division of Digestive and Liver Diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
与医疗保健工作者相比,患有炎症性肠病 (IBD) 的人对COVID-19疫苗的副作用较少. 大多数疫苗反应都是轻微而短暂的,解决了IBD患者的安全问题.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 由于安全性数据有限,疫苗犹是炎症性肠病 (IBD) 患者群体的一个担忧.
- 对IBD患者疫苗安全性的比较研究对于明智决策至关重要.
研究的目的:
- 为了比较IBD患者和健康医疗保健工作者 (HCW) 之间的疫苗接种后症状.
- 评估IBD患者在SARS-CoV-2mRNA疫苗接种后症状的频率,严重程度和持续时间.
主要方法:
- 一项涉及IBD患者和HCWs的全国性比较研究.
- 通过对1剂和2剂后的调查收集的症状数据.
- 统计分析包括威尔科克森等级和,费舍尔的精确测试和回归分析.
主要成果:
- 与HCW相比,IBD患者在接种两剂疫苗后报告的接种后症状较少.
- 大多数症状都是轻微的,在两组的两天内都消失了.
- 胃肠道症状在IBD患者中在第一剂后更频繁,但第二剂后没有.
结论:
- 患有IBD的个人通常比HCW体验的疫苗接种后症状较少和较轻.
- 对于IBD患者来说,SARS-CoV-2 mRNA疫苗似乎是安全的,主要是轻微和短暂的副作用.
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