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在慢性病中高循环内分泌? 一个系统的审查和元分析
Amirmohammad Khalaji1,2, Amir Hossein Behnoush1,2, Yasmin Mohtasham Kia3
1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
PloS one
|August 9, 2023
概括
在患有慢性病 (CKD) 的患者中,Endocan水平显著升高. 这一发现表明内分泌可能在CKD中发挥作用,并需要进一步研究其诊断和预后潜力.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物 生物标志物
- 内皮细胞生物学 内皮细胞生物学
背景情况:
- 慢性病 (CKD) 是一个主要的全球健康问题,与严重的发病率和死亡率有关.
- 内皮功能障碍与CKD的病理生理学有关.
- 内皮细胞因子Endocan在各种疾病状态中升高.
研究的目的:
- 系统地审查和元分析内分泌水平与CKD之间的关联.
- 为了比较CKD患者与健康对照者的循环内分泌水平.
主要方法:
- 在PubMed,Embase,Scopus和Web of Science数据库中进行系统搜索.
- 随机效应元分析用于计算标准化平均差异 (SMD) 和95%置信区间 (CI).
- 根据样品类型 (血清或血) 进行子组分析.
主要成果:
- 在分析中包括了20项研究.
- 与健康对照组相比,CKD患者表现出显著更高的内分泌水平 (SMD1.34,p<0.01).
- 在血清和血子组以及在没有并发症的CKD患者中观察到升高的内分泌量 (SMD 0.74,p<0.01). 在CKD中,Endocan也与心血管疾病有关.
结论:
- 在患有CKD的患者中,Endocan水平显著增加.
- 这种升高对CKD管理有潜在的临床影响.
- 需要进一步的研究来探索内分泌在CKD的诊断和预后价值.
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