头皮疾病中的肉毒毒素:系统性审查
Betty Nguyen1,2, Sofia M Perez1, Antonella Tosti1
1Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.
概括
毒素 (BTX) 在治疗头皮疾病,如脱发和超等方面表现有前途. 虽然证据各不相同,但BTX可能提供一种治疗选择,但需要进一步的研究来确认疗效和安全性.
科学领域:
- 皮肤病学 皮肤病学
- 审美医学是一种美学医学.
- 头发修复 恢复头发的方法
背景情况:
- 许多病例报告记录了毒素 (BTX) 用于头皮问题.
- 缺乏关于BTX治疗头皮疾病的现有研究结果的全面综合.
研究的目的:
- 系统地审查和总结用BTX治疗的头皮疾病.
- 评估BTX在头皮治疗中的有效性的现有证据基础.
主要方法:
- 在PubMed/MEDLINE和Scopus进行了系统的文献搜索.
- 关键词包括"头发"或"头皮"与BTX相关术语相结合.
- 包括文章描述了BTX注射用于头皮状况管理.
主要成果:
- 分析了涉及309名患者的24篇文章.
- 雄激素性脱毛症,面过和头皮过重显示出BTX疗效的最强有力的证据.
- 数据质量高度变化,通常仅限于小型观察性研究.
结论:
- 毒素 (BTX) 对各种头皮疾病具有潜在的有前途的治疗选择.
- 进一步的高质量研究对于建立最终的疗效和安全性概况至关重要.
- 目前的证据有限,需要更严格的临床试验.
相关概念视频
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
703
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
The binding of dantrolene to the RYR1...
703
Skeletal Muscle Relaxants: Therapeutic Uses
514
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
514


