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通过产量可扩展的SARS-CoV-2mRNA脂质纳米粒子疫苗的制造

Sarah J Shepherd1, Xuexiang Han1, Alvin J Mukalel1

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.

Proceedings of the National Academy of Sciences of the United States of America
|August 9, 2023
PubMed
概括

一个新的微流体芯片使得可扩展的,精确的脂质纳米颗粒 (LNP) 的生产为mRNA疫苗和疗法. 这项技术在制造规模上保持了LNP的质量和功效,为商业化铺平了道路.

关键词:
药物输送是药物输送的过程.它们是mRNARNA.纳米医药是一种纳米医药.纳米颗粒是一种纳米粒子.疫苗,疫苗的使用情况.

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Conjugated Proteins02:50

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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
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