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大脑节律通过NF-κB信号传递控制微质反应和细胞因子表达

Ashley Prichard¹, Kristie M Garza^1,2, Avni Shridhar¹

¹Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.

Science advances

|August 9, 2023

概括

像玛和β波这样的大脑节奏会改变微质细胞和细胞因子的信号传递. 核因子kB (NF-kB) 调解这些频率特异性反应,影响大脑功能.

科学领域:

神经科学是一个神经科学.
神经免疫学神经免疫学
细胞生物学细胞生物学

背景情况:

微质,大脑的免疫细胞,对神经活动的变化做出反应.
独特的大脑节奏 (神经频率) 对微质和细胞因子信号传递的特定影响仍然在很大程度上未被探索.

研究的目的:

研究特定的大脑节奏,即40 Hz (波段) 和20 Hz (β波段) 神经活动如何影响微质形态和细胞因子表达.
确定核因子 κB (NF-κB) 信号在调解这些频率特定的微质和细胞因子反应中的作用.

主要方法:

在健康的动物中利用非侵入性的视觉闪感官刺激 (闪) 来诱导40Hz和20Hz的有针对性的神经活动.
分析了微质形态,并量化了特定细胞因子的表达 (例如,互白素-10,巨细胞殖民地刺激因子).
研究了-NF-κB的激活和局部化,并评估了NF-κB信号抑制的影响.

主要成果:

不同的大脑节奏 (40 Hz与20 Hz闪) 明显改变了微质形态和细胞因子表达.
某些细胞因子,包括互乐金-10和巨细胞殖民地刺激因子,是独立于直接的微质参与诱导的.
-NF-κB主要与神经元在闪后同位,NF-κB抑制减少了闪诱导的细胞因子表达和微质变化.

结论:

大脑节律通过NF-κB通路差异调节微质形态和细胞因子配置.
这项研究揭示了一种机制,它将神经振荡与神经免疫反应联系起来,影响大脑的整体功能.

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