来自老年已故捐赠者的移植的结果:一个单中心研究
Kris Magerl1, Matthias Diebold1, Caroline Wehmeier1
1Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.
Swiss medical weekly
|August 9, 2023
概括
来自70岁以上捐赠者的移植显示了与年轻捐赠者的可比的移植存活率. 虽然eGFR与常规捐赠者相比较低,但非常古老的捐赠脏为移植提供了一个可行的选择.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 老年医学 老年医学
背景情况:
- 鉴于人口结构的变化,评估来自非常老年 (70岁以上) 捐赠者的移植结果至关重要.
- 这项研究探讨了在移植中使用老年捐赠脏的疗效和安全性.
研究的目的:
- 分析移植受体患者和移植结果,按捐赠者的年龄分层分层.
- 为了比较非常老年,老年人和常规捐赠者的移植成功率.
主要方法:
- 从前性观察性移植队列中对491名患者的回顾性分析.
- 根据供体年龄对患者进行分层:非常老 (>70岁),老年 (60-70岁) 和常规 (<60岁).
- 主要结局:死亡审查的移植存活率;次要结局包括估计的淋巴细胞过率 (eGFR) 和急性排斥发作.
主要成果:
- 在三个捐赠者年龄组中,死亡审查的移植损失没有统计学上显著的差异 (p=0.37).
- 在非常老的捐赠者群体中,3年/5年死亡审查的移植存活率为96%/86%,与其他群体相比 (p=0.44).
- 虽然在与常规捐赠者相比,非常老和老年捐赠者群体的EGFR较低 (p<0.0001),但急性排斥率没有显著差异 (p=0.11).
结论:
- 使用精心挑选的非常老的捐赠者进行移植是一种可行的选择.
- 来自非常资深的捐赠者的移植的短期和中期结果是合理的,与年轻的捐赠者相比.
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