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Updated: Jul 19, 2025

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
08:00

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

Published on: October 4, 2024

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用机器学习工具蛋白MPNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN

Hsi-Wen Kao1, Wei-Lin Lu1, Meng-Ru Ho1

  • 1Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.

ACS synthetic biology
|August 9, 2023
PubMed
概括

研究人员使用深度学习重新设计了ubiquitin变体 (UbVs),以增强Rsp5 E3酶活性. 三个UbV显示出低微分子结合亲和力,R4和R12增强了Rsp5功能的六倍.

关键词:
阿尔法折叠是什么意思阿尔法折叠在HECT E3结合酶中.蛋白质MPNNN 蛋白质MPNN在Rsp5中使用Rsp5.乌比奎丁的变种 乌比奎丁变种

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