冠状动脉化与左心室全球纵向应变和透析参数之间的关联:ELSA-巴西研究
Priscila Haas1, Angela B S Santos1, Wilson Cañon-Montañez2
1Postgraduate Program in Cardiology and Cardiovascular Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
The American journal of cardiology
|August 9, 2023
概括
冠状动脉化 (CAC) 与无症状个体左心室 (LV) 功能受损有关. 虽然常见的风险因素解释了这种关联的大部分,但在男性中,它似乎是独立的.
科学领域:
- 心脏病学 心脏病学
- 放射学 放射学是指放射学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 亚临床动脉样硬化,以冠状动脉化 (CAC) 为标志,可能会在临床心血管事件之前发生.
- 左心室 (LV) 功能障碍,通过全球纵向应变 (GLS) 和透气参数进行评估,可以是心脏妥协的早期迹象.
研究的目的:
- 为了研究冠状动脉化 (CAC>0) 和无症状个体中LV功能参数受损的存在之间的关联.
- 为了确定这种关联是否在考虑传统的心血管风险因素之后仍然存在.
主要方法:
- 来自ELSA-巴西队列的数据分析,包括无症状的参与者,心脏计算机断层扫描用于CAC和心声回声扫描用于LV功能.
- 在有和没有CAC的个体之间比较GLS和腹功能参数 (心肌E/e',隔膜E',侧面E') .
- 统计分析以评估相关性和关联的独立性,调整糖尿病,肥胖,高血压,吸烟和LDL胆固醇.
主要成果:
- 33.17%的参与者 (n=612) 的CAC>0.
- CAC>0与更糟糕的扩张功能参数 (较高的 mitra E / e,较低的隔膜和侧面 e') 相关,特别是在男性中.
- 绝对CAC值与GLS没有相关性,但与透缩参数有相关性.
- 关联在很大程度上是由心血管风险因素解释的,除了男性的 mitra E / e' 和 septal E' ,它们仍然是显著的.
结论:
- 亚临床冠状动脉样硬化 (CAC>0) 与LV透静功能受损有关.
- 常见的心血管风险因素对这种关联有显著的贡献.
- 特别是在男性中,CAC>0和LV扩张功能受损之间存在独立的关联.
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