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丁酸在老鼠中减轻了丁素诱导的毒性

Morteza Saeedavi¹, Mehdi Goudarzi², Iman Fatemi³

¹Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

|August 9, 2023

概括

丁酸 (GA) 通过减少氧化应激和炎症来保护 gentamicin (GEN) 诱导的损伤. 这项研究表明GAGA.

科学领域:

药理学药理学是指药理学的学科.
毒理学毒理学毒理学
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

甘他素 (GEN) 是一种已知会引起毒性的抗生素.
氧化应激和炎症是GEN诱导损伤的关键机制.
甘酸 (GA) 正在研究其潜在的保护性质.

研究的目的:

为了评估 gentisic 酸 (GA) 对大鼠 gentamicin (GEN) 诱导的毒性的保护作用.
评估GA对氧化应激,炎症标志物和GEN暴露后功能的影响.

主要方法:

在14天的时间里,老鼠口服了不同剂量的GA (25,50,100毫克/公斤).
从第8天到第14天,Gentamicin (100 mg/kg) 通过腹膜内注射.
分析了损伤,氧化应激 (MDA,GSH),炎症 (TNF-α,IL-1β) 和抗氧化酶活动 (CAT,SOD,GPx) 的血清和组织标志物.

主要成果:

基因基因的使用显著增加了损伤 (NGAL,KIM-1,BUN,Cr) 和氧化应激 (MDA,NO) 的标志物.
在组织中,GEN暴露增加了炎症性细胞因子 (TNF-α,IL-1β) 和降低了抗氧化酶活性 (CAT,SOD,GPx).
抗氧化酶治疗显著缓解了GEN诱导的损伤标志物,氧化应激和炎症的增加,同时恢复了抗氧化酶活性.

结论:

甘酸 (GA) 显示出显著的脏保护作用,防止甘胺 (GEN) 诱导的脏损伤.
通过减轻氧化应激和抑制炎症反应,GA改善了GEN诱导的毒性.
GA具有作为预防或治疗抗生素诱导损伤的治疗剂的潜力.

关键词:

这是一种 gentamicin.甘酸是什么甘酸是什么炎症炎症是一种炎症.毒性毒性毒性氧化应激是一种氧化应激.

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