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Axel R Schulz¹, Leonard Fiebig¹, Heike Hirseland¹

¹Deutsches Rheuma-Forschungszentrum Berlin, A Leibniz Institute, Berlin, Germany.

|August 9, 2023

概括

在mRNA疫苗接种后,骨髓中的SARS-CoV-2特异性血细胞 (PC) 可以发展记忆表型. 这表明,针对SARS-CoV-2的基本mRNA疫苗接种可以诱导持久的幽默免疫力.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
细胞生物学细胞生物学

背景情况:

在感染或接种疫苗后,SARS-CoV-2 特定抗体分泌血细胞 (PC) 在人类骨髓 (BM) 中被发现.
以前还不清楚这些PC是否会发展出记忆表型.

研究的目的:

在mRNA疫苗接种后,研究人类骨髓中SARS-CoV-2特异性血细胞的表型.
为了确定在SARS-CoV-2疫苗接种后是否建立了记忆血细胞表型.

主要方法:

使用基于四聚体的抗原特异流细胞计,对SARS-CoV-2特异的人类骨髓血细胞 (BMPC) 的表征.
使用FluoroSpot测定来分析BMPC群体.

主要成果:

在所有已接种疫苗的BM样本中检测到SARS-CoV-2尖端-S1特异性PC,占总BMPC的0.22%.
这些BMPC中的大多数表达了IgG,表明了针对尖端S1蛋白的全身疫苗接种反应.
大约五分之一的SARS-CoV-2特异性BMPC表现出记忆血细胞表型 (下调CD19,变异CD45表达).

结论:

在基本的mRNA免疫接种后,在人类骨髓中建立了具有表型多样性的SARS-CoV-2特定PC,包括记忆表型.
这些发现表明,针对SARS-CoV-2的基本mRNA疫苗接种会诱导持久的幽默免疫力.

关键词:

CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD45 CD45 CD45 CD45 CD45 CD45 CD45 CD45 CD45 CD45 CD45 CD45 CD45 CD45 CD45 CD45 CD45 人类骨髓是人类的骨髓.幽默记忆是一种幽默记忆.长寿等离子体细胞长寿等离子体细胞这就是SARS-CoV-2病毒.

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