环境PM₁₀和PM_2.5与使用选择性冠状动脉血管学测量的冠状动脉狭窄的相关性

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Updated: Jul 19, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

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Published on: March 15, 2022

Manqing Luo¹, Xiaowei Xie², Jieyu Wu³

¹Department of Cardiology, Fujian Provincial Hospital, Shengli Clinical Medical College, Fujian Medical University, Fuzhou, China; Fujian Provincial Key Laboratory of Cardiovascular Disease, Fujian Provincial Center for Geriatrics, Fujian Provincial Clinical Research Center for Severe Acute Cardiovascular Diseases, Fuzhou, China; Fujian Heart Failure Center Alliance, Fuzhou, China.

Ecotoxicology and environmental safety

|August 9, 2023

概括

长期暴露于细颗粒物 (PM10和PM2.5) 与冠状动脉狭窄有关. 较高的颗粒物水平与严重程度的增加相关,并确定了潜在的调解者.

科学领域:

环境健康环境健康
心血管医学心血管医学
流行病学流行病学

背景情况:

长期暴露于环境颗粒物 (PM) 对心血管健康产生不利影响.
关于长期暴露于PM10和PM2.5与冠状动脉狭窄之间存在关联的证据有限.
这项研究研究了在接受血管造影的患者中PM10,PM2.5和冠状动脉狭窄之间的关系.

研究的目的:

确定长期暴露于PM10和PM2.5与冠状动脉狭窄程度之间的关联.
确定PM暴露和冠状动脉狭窄之间的关系中的潜在调解因素.

主要方法:

在中国 (2019-2021) 接受冠状动脉血管造影的7513名患者进行了回顾性队列研究.
使用修改的根西尼分数 (GS) 量化冠状动脉狭窄.
采用线性回归,物流模型,受限立方线和调解分析来评估PM暴露-GS关系和潜在的调解者.

主要成果:

长期暴露于PM10和PM2.5显示出与冠状动脉狭窄 (GS) 有显著的积极关联.
在断点度以上观察到线性关系 (PM10: 47.5 μg/m3,PM2.5: 25.8 μg/m3).
增加的PM暴露与严重冠状动脉狭窄的更高几率相关,已确定包括胆固醇,肌氨酸和HbA1c在内的潜在媒介.

结论:

这项研究提供了新的证据,将慢性PM10和PM2.5暴露与冠状动脉狭窄症联系起来.
这些发现强调了PM暴露是冠状动脉疾病严重程度的危险因素.
确定了涉及代谢和脏标记物的潜在调解途径.

关键词:

血管学血管学血管学动脉样硬化是一种动脉样硬化.冠状动脉狭窄症冠状动脉狭窄症流行病学流行病学颗粒物质颗粒物质是什么

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