尿中氨基PAH与柴油发动机排放和尿中变异性相关
Junfeng Jim Zhang1, Yuxin Zheng2, Roel Vermeulen3
1Nicholas School of the Environment and Duke Global Health Institute, Duke University, Durham, NC, USA; Duke Kunshan University, Kunshan City, Jiangsu Province, China.
International journal of hygiene and environmental health
|August 9, 2023
概括
在柴油发动机测试器中尿中的1-氨基烯水平表明暴露于有害排放. 这种代谢物与柴油暴露和突变性有很强的相关性,作为可靠的生物标志物.
科学领域:
- 环境健康 环境健康
- 职业医学 职业医学是专业的.
- 毒理学 毒理学 毒理学
背景情况:
- 柴油废气是已知的人类致癌物,但具体的致病原体尚不清楚.
- 化多环芳 (NPAHs) 是可疑的贡献者,其中1 - 酸和2 - 酸可能大量存在于柴油废气中.
- NPAHs的尿路代谢物可以作为暴露和相关健康风险的生物标志物.
研究的目的:
- 调查NPAHs尿氨基代谢物与高柴油发动机排放之间的关联.
- 评估这些代谢物,柴油暴露和职业暴露工人的尿路变异性之间的关系.
- 为了确定尿中的1-aminopyrene是否可以作为柴油发动机排放和变异性生物标志物.
主要方法:
- 从54名柴油发动机测试人员和55名对照人员收集了点滴尿样.
- 使用液态染色体质谱分析了五种NPAH氨基代谢物和丁氨酸.
- 通过呼吸区测量评估个人对微粒 (PM2.5),元素碳和烟尘的暴露.
- 使用沙门氏菌 (Ames) 试验与菌株YG1041.1测量非吸烟参与者的子组的变异性.
主要成果:
- 与对照组相比,发动机测试人员的1-aminopyrene和2-aminofluorene的患病率明显高于对照组.
- 在发动机测试者中,尿液中的1-aminopyrene度升高,并且与烟灰,元素碳和致变性强烈相关.
- 吸烟没有影响1-aminopyrene水平或与柴油暴露的关联,与2-aminofluorene不同.
结论:
- 尿中的1-aminopyrene是评估暴露于柴油发动机排放的可靠生物标志物.
- 高水平的1-aminopyrene与与柴油废气暴露相关的突变性增加有关.
- 这一发现有助于理解柴油废气的致癌性,并监测工人暴露.
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