一个混合的微晶纤维素/金属有机框架,用于分散固相微提取选定的药品:一个概念验证
Reda M Abdelhameed1, Sherin F Hammad2, Inas A Abdallah3
1Applied Organic Chemistry Department, Chemical Industries Research Institute, National Research Centre, Giza 12622, Egypt.
Journal of pharmaceutical and biomedical analysis
|August 9, 2023
概括
研究人员比较了Ca-BTC MOF和Ca-BTC-MCC MOF混合物用于固相微提取 (SPME). 在大多数药物中,Ca-BTC MOF的提取效率更高,这突显了吸附剂形态和分析物质特性的重要性.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
背景情况:
- 固相微提取 (SPME) 是一种首选的样品制备技术,因为它简单,环保,和成本效益.
- 开发具有增强表面积的新型吸附材料对于提高分析化学中的提取效率至关重要.
研究的目的:
- 首次对Ca-BTC MOF和混合Ca-BTC-MCC MOF作为SPME的吸附剂进行比较分析.
- 评估这些吸附剂的提取效率,用于具有不同物理化学性质的七种模型药物化合物.
主要方法:
- 利用固相微提取 (SPME) 采用两种不同的金属有机框架 (MOF) 基吸附剂:Ca-BTC MOF和混合Ca-BTC-MCC MOF.
- 使用高性能液态染色学与二极管阵列检测 (HPLC/DAD) 在反相,同位素化模式下分析了提取效率.
主要成果:
- 与Ca-BTC-MCC MOF相比,Ca-BTC MOF在大多数测试药物分析物中表现出更高的提取效率.
- 尼尔马特里尔维尔和里托纳维尔是例外,它们在Ca-BTC-MCC MOF混合物中显示出更高的提取率.
- 吸附能力不仅受到表面积的影响,还受到吸附剂形态和分析物的物理化学性质的影响.
结论:
- 这项研究表明了Ca-BTC MOF及其在SPME中的混合对应物的差异性性能.
- 结果强调,吸附剂形态和分析物质的特性在确定提取效率方面发挥着重要作用,而不仅仅是表面积.
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