相关实验视频

Updated: Jul 19, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

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一个与膜相关的MHC-I抑制轴用于癌症免疫规避

Xufeng Chen1, Qiao Lu1, Hua Zhou2

  • 1Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA; The Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA.

Cell
|August 9, 2023
PubMed
概括

研究人员发现了一种新的癌症免疫规避机制,涉及表面蛋白质SUSD6,TMEM127和WWP2,它抑制了主要组织相容性复合体I类的呈现. 针对这一轴可以改善癌症免疫治疗反应.

关键词:
标签:MHC-I美国6一个T细胞没有.在WWP2抗原呈现方式癌症免疫逃避溶酶体降解无处不在

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