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宫阴道微生物免疫状态和B组链球菌在怀孕期间的殖民化
Jennifer A McCoy1, Heather H Burris1,2, Kristin D Gerson1
1Department of OB/GYN, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
American journal of perinatology
|August 9, 2023
概括
某些阴道细菌群体 (CST IV-A和CST II) 在孕妇中增加B组链球菌 (GBS) 殖民风险. 免疫因子β-defensin-2修改了这种关联,表明了针对微生物群的潜在预防策略.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 产科 产科 产科 产科 产科
背景情况:
- 孕产妇B组链球菌 (GBS) 殖民是新生儿发病的主要危险因素.
- 关于宫性阴道 (CV) 微生物群和β-防御素-2在怀孕期间对GBS殖民的影响的数据有限.
研究的目的:
- 在怀孕的个体中调查CV微生物群和GBS殖民之间的关联.
- 为了确定免疫因子β-defensin-2是否会改变CV微生物群和GBS殖民之间的关系.
主要方法:
- 怀孕个体前性队列研究 (n=492) 的二次分析.
- 使用16S rRNA基因测序分析的CV微生物群,并将其分类为社区状态类型 (CST).
- 逻辑双项回归模拟了CST和GBS直阴 (RV) 培养状态之间的关联,而β-defensin-2作为效果修饰剂进行了检查.
主要成果:
- 34.3%的个人是GBS RV阳性.
- 与CST I相比,CST IV-A和CST II与GBS RV殖民的风险显著增加,与CST I相比.
- β-defensin-2修改了CST IV-A关联;高水平否定了低水平观察到的增加的GBS风险 (相互作用p=0.03).
结论:
- 特定的CV微生物群概况 (CST IV-A,CST II) 与妊娠晚期GBS殖民风险的增加有关.
- 贝塔-防御素-2 作为效果修饰剂,影响 CST IV-A 对 GBS 状态的影响.
- 未来的研究可以探索CV微生物群操纵GBS预防,可能减少抗生素使用和新生儿感染风险.
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