与甲状腺相关的荷尔蒙变化预测了人类测量尺度的变化和中国甲状腺正常人肥胖的发生率
Ling Deng1,2, Xiaoxia Zheng2, Ping Shuai2
1Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.
概括
在正常范围内甲状腺激素的变化预测肥胖风险. 甲状腺刺激激素 (TSH),自由三甲状腺素 (FT3) 和自由甲状腺素 (FT4) 的微小变化也会影响体重指数 (BMI) 和腰围 (WC).
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 甲状腺激素在调节新陈代谢方面发挥着至关重要的作用.
- 甲状腺功能的微妙变化在甲状腺功能范围内可能会影响身体组成.
- 肥胖是一个日益严重的全球健康问题,具有复杂的促成因素.
研究的目的:
- 检查甲状腺激素水平变化与人类测量测量之间的关联.
- 为了确定甲状腺激素波动是否预测了 euthyroid个体肥胖的发生率.
- 研究甲状腺相关生物标志物对体重指数 (BMI) 和腰围 (WC) 变化的预测价值.
主要方法:
- 分析了4850名在基线和随访时甲状腺功能正常的受试者的数据.
- 评估血清甲状腺刺激激素 (TSH),自由三甲状腺素 (FT3) 和自由甲状腺素 (FT4) 度的变化.
- 统计建模以评估甲状腺激素变化与人体指标 (包括BMI和WC) 之间的关系.
主要成果:
- 在无甲状腺男性和女性中,TSH,FT3,FT4的变化和FT3/FT4比率的变化独立预测了BMI和WC的变化.
- 增加FT3/FT4比率与显著更高的肥胖风险相关 (7.144-7.572倍).
- FT4水平的降低与肥胖风险降低 (21.0%-26.9%的风险降低) 有关.
结论:
- 甲状腺激素在参考范围内的变化与人类测量指标的变化有关.
- 甲状腺激素动态可以作为BMI,WC和肥胖发病率变化的预测因素.
- 这些发现强调了监测甲状腺功能的重要性,即使在代谢健康评估的正常范围内.
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