个别前额神经元通过在空间工作记忆表现过程中旋转参考框架来促进感觉到运动信息的转换
Shintaro Funahashi1,2,3,4, Binbin Gao2, Kazuyoshi Takeda3
1Advanced Research Institute for Multidisciplinary Science, Beijing Institute of Technology, Haidian District, Beijing 100018, People's Republic of China.
Cerebral cortex (New York, N.Y. : 1991)
|August 9, 2023
概括
前额神经元通过在延迟期间改变参考框架将视觉工作记忆转化为运动指令. 这项研究阐明了大脑如何将感官输入转化为可操作的运动计划.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 灵长类动物研究研究
背景情况:
- 工作记忆包括维护和转换信息.
- 前额叶皮层 (PFC) 在工作记忆和决策中起着至关重要的作用.
- 在PFC中,视觉转化为运动转化的精确神经机制尚不清楚.
研究的目的:
- 在延迟反应任务期间,研究单个前额神经元在视觉到运动信息转换中的作用.
- 为了检查神经表现如何在延迟期内发生变化.
- 阐明工作内存背后的参考框架转换.
主要方法:
- 记录了子中前额神经元的延迟周期活动,这些神经元执行了延迟的萨卡德任务.
- 分析神经活动偏好的方向的时间变化.
- 使用了一项任务,需要在3秒的延迟后从视觉提示中以时针方向向90°的方向跳动.
主要成果:
- 确定了参与信息转换的前额神经元的不同组.
- 观察到神经元维持视网膜类参考框架或反时钟方向旋转它们.
- 发现神经元使用以时钟轴为基础的参考框架和顺时针旋转信息.
- 证明视觉转化为机器的转化涉及对参考框架的操纵.
结论:
- 前额叶皮层利用不同的神经元群体和参考框架操纵来实现视觉到运动转换.
- 参考框架的动态调整对于将感觉信息转换为运动指令至关重要.
- 这项研究提供了关于目标导向行为和工作记忆的神经基础的见解.
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