专与球蛋白的比率在诊断周围假肢关节感染方面表现良好:单中心回顾性研究
Mingjie Dong1, Yushan Wang1, Hao Fan1
1Department of Orthopaedics, The Second Clinical Medical College of Shanxi Medical University, TaiYuan, China.
The Journal of arthroplasty
|August 9, 2023
概括
专蛋白与球蛋白比率 (AGR) 显示出对诊断周围假肢关节感染 (PJI) 的希望,与ESR和CRP等既有标志物相美. 将AGR与其他标记物,如全球蛋白 (GLB) 和C反应蛋白 (CRP) 结合起来,可以提高PJI的诊断准确性.
科学领域:
- 整形外科手术 整形外科手术
- 传染性疾病 传染性疾病
- 诊断生物标志物 诊断生物标志物
背景情况:
- 准确诊断周围假肢关节感染 (PJI) 是一个重要的临床挑战.
- 现有的PJI诊断方法需要提高准确性和效率.
研究的目的:
- 评估白蛋白与全球蛋白比率 (AGR) 和全球蛋白 (GLB) 对周围假肢关节感染 (PJI) 的诊断效用.
- 将AGR和GLB的诊断性能与已确定的炎症标志物进行比较.
主要方法:
- 分析了182名接受修复关节整形手术的患者队列.
- 用接收器操作特征 (ROC) 曲线来评估AGR,GLB,红细胞沉积率 (ESR) 和C反应蛋白 (CRP) 的诊断值.
主要成果:
- 在膝盖 (AUC:0.940) 和部 (AUC:0.855) PJI病例中,AGR显示出高的诊断准确性.
- 确定AGR的最佳截止值为膝盖PJI的1.375和部PJI的1.295.
- 结合的标志物,如"AGR或ESR"和"AGR和GLB",在膝盖组显示出出色的灵敏度 (99.6%) 和特异性 (98.9%).
结论:
- 白蛋白与球蛋白比率 (AGR) 是诊断PJI的有价值的生物标志物,其性能与ESR和CRP相比.
- AGR和GLB,以及CRP和ESR,被推作为PJI诊断的首选指标.
- 这些标记物的特定组合提供了卓越的诊断性能,特别是在膝盖PJI病例中.
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